2006 (Sophomore): Started all 12 games for the Crimson Tide. He finished the season with a passing efficiency of 128.92, completing 198-of-346 passes for 2,539 yards, 16 touchdowns and nine interceptions. He threw for over 200 yards in the first seven games of the season, setting a new school record, and finished with a school record nine 200-yard games. He had six games with two or more touchdown passes and threw at least one touchdown pass in nine contests. Wilson also recorded 76 carries for 73 yards with a long of 27. He finished the season ranked in the top-five of most single season passing categories at Alabama. He set the school record for passing yards and pass attempts, tied the record for touchdowns and finished third in completions. He completed 16 of his 29 attempts for 253 yards and a touchdown in his first career start against Hawaii.