Id say take. Tackles working up to the second level to take on Warner, TE appears to be doing the same, but I'm not exactly sure by just the picture if that's what he's doing, or if he's going out for a designed route. If he's working up to take on the Safety, then most certainly he should take it. That's a good amount of space for Jackson, and he has the ability to make them miss, or split between the defenders and take it to the house, or for a big gain. There's almost nowhere for the RB to go either, that entire side is played extremely well, linebacker fit the A gap correctly, D-lineman is filling the B gap, he could try to bounce it outside, but the DB would probably come downhill and fit that spot up as well. So, Jackson should keep it, he's got the best chance to make something out of it.