Bama1966 said:
Tuscaloosa to Birmingham, take I-20 east, I also believe it is I-59 North, and you will go directly to Birmingham. Mcfarland Blvd will run you into 59/20 junction.
Birmingham to Tuscaloosa is I-59 South/ I-20 West follow the signs to Tuscaloosa.
Actually, take I-459 West to I 20/59 West and South to any Tuscaloosa exit. Or, get off at exit 100 and take a right, which will take you through Brookwood on Al HWY 216 (usually lighter traffic). This comes out at 15th Street and University Blvd. Take a right on University, and follow the traffic.