We usually go 69S, through Greensboro, get on 25, head south until it hits 5 near Thomasville... it merges onto 43 S there. Take that all the way to Creola and get on I-65 in Mobile. Just do the reverse to get up here obviously (easier to miss turns on the way up of you are not familiar with the route, so use GPS or pay close attention). And WATCH FOR SPEED TRAPS.
Going into Meridian via I-20 and taking HWY 45 all the way into Mobile is another route... more miles, and the birds wouldn't go that way, but you can fly on most of the roads and there are very few cops running radar on that route (i.e. I've never seen one in multiple trips). The only bad part is going into/coming out of Mobile for a good while, it's a 2 lane road...