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When the game is out of hand (the lead is too great to overcome) you usually begin to see second, third and fourth team players coming into the game for the leading team and even the team that is behind.  The quality of play isn't typically the same as when the first-teamers are playing.  This period of time is usually referred to as "garbage time."  If the team that is behind scores points, it doesn't impact the end result (instead of winning 45-0, the winning score becomes 45-7).  At the same time, a backup on the winning team could score moving the score from 45-0 to 52-0.  The only impact is on people who bet the spread or total points.